Cerebrovascular diseases and neurodegenerative diseases
- Stroke: large, mouse, non-human primate focal cerebral ischemia model; rat focal cerebral hemorrhage model.
- Parkinson's disease: a bilateral model of Parkinson's disease in nonhuman primates.
- Alzheimer's disease: scopolamine model; APP/PS1/TAU three-transgenic model; rat 2VD/3VD model.
Metabolic diseases
- Hyperlipidemia: food-induced hyperlipidemia model in guinea pigs, rats, and mice, and growth hormone deficiency hyperlipidemia model.
- Obesity: food-induced obesity model in rats and mice, cynomolgus monkey obesity model, ob/ob mouse model.
- Diabetes: STZ-induced type Ⅰ and type Ⅱ diabetes models in rats and mice, db/db, ZDF type Ⅱ diabetes models.
- Hyperuricemia: rat hyperuricemia model induced by uric acid, adenine + oxacinate potassium, yeast-induced chicken hyperuricemia model.
- Sugar clamp test in rats, dogs and pigs.
Respiratory diseases
- Pneumonia: LPS-induced single-hit and double-hit pneumonia models.
- Pulmonary fibrosis: BLM-induced pulmonary fibrosis models in rats and mice.
- Respiratory distress syndrome: BLM-induced ARDS model in rats.
- Bronchial asthma: OVA, histamine & acetylcholine-induced asthma models in rats and guinea pigs.
Liver disease
- Liver fibrosis: CCL4-induced chronic liver fibrosis model in rats and mice, DIO mouse + CCL4-induced NASH model, MCD mouse model.
- Immune hepatitis: CoNA-induced acute hepatitis model in mice.
- Drug-induced liver damage: acute and chronic liver damage models induced by APAP and D-gal in mice.
- Cholestatic liver damage: bile duct ligation-induced liver damage model in rats and mice.
- Liver failure: D-gal-induced liver failure model in pigs and mice, 85% hepatectomy-induced liver failure model in rats and pigs.
Kidney disease
- Rat renal injury model induced by ureteral ligation and renal ischemia-reperfusion.
Digestive system diseases
- Colitis: DSS-induced mouse UC model.
- Anal swelling (hemorrhoids): acetic acid, croton oil-induced anal swelling model in rats.
Reproductive system diseases
- Endometrial injury: ethanol-induced endometrial injury model in rats.
- Endometriosis: rat autologous endometriosis model.
Pain
- Hot plate model, thermal radiation pain model, mouse writhing (abdominal pain) model, joint pain (tenderness) model.
Arthritis
- Rheumatoid arthritis: CFA-induced rat AA model, xenogeneic collagen + CFA (IFA-induced) cynomolgus monkey CIA model.
- Gouty arthritis: an arthritis model induced by intra-articular injection of MSU.
- Osteoarthritis: cruciate ligament + meniscectomy, MIA-induced rat and rabbit OA models.
Cardiovascular DepartmentSystemic diseases
- Myocardial infarction: rat and dog myocardial infarction model induced by coronary artery surgery.
- Thrombus: arterial, deep vein, arteriovenous thrombosis model.
- Hypertension: SHR essential hypertension rat model, renovascular hypertension rat model.
Biologics
- Efficacy evaluation and in vivo activity determination of growth hormone, insulin, and follicle-stimulating hormone.
Osteoporosis
- Rat osteoporosis model induced by retinoic acid, parathyroidectomy, and gonadectomy.
Immune system
- Glucocorticoid-induced immunosuppression model in mice.
